Endocrine Abstracts

Introduction and objective: Treatment with integrated continuous subcutaneous insulin infusion (CSII) and continuous glucose monitoring systems (CGM) helps to improve glycaemic control in people with type 1 diabetes mellitus (DM1). There is increasing use in pregnant women, but there are no protocols for its continuation during delivery. The aim of this work is to analyse glycaemic control during pregnancy, in addition to studying obstetric and neonatal outcomes.<p class="...

Introduction and Objectives: Despite the many known advantages of Flash Glucose Monitoring (FGM), very few studies have shown a real improvement in the patient’s overall quality of life. Therefore, our aim is to assess, using the validated Diabetes Mellitus Specific Quality of Life Questionnaire: Spanish version (EsDQOL), whether these differences really exist in our population.Methods: An observational, prospective study was conducted comparing qua...

Introduction: Eating disorders (ED) are prevalent psychiatric conditions with significant nutritional implications, posing a risk of life-threatening illness for patients. The chronic and recurrent nature of these disorders, along with normal laboratory test results, present challenges in their management and ongoing monitoring, which typically focuses on weight changes. Techniques like determining the phase angle using bioimpedance analysis or conducting functional muscle tes...

Introduction: Even Though resection via transsphenoidal surgery is the optimal primary treatment for growth hormone (GH) secreting pituitary adenomas, medical therapy must also be considered when biochemical control after surgery is not achieved. The aim of our study was to describe the cure rates of acromegaly patients after different lines of therapy.Methods: A retrospective study (1971–2022) of 89 patients diagnosed with acromegaly was conducted....

Introduction: The silencing mechanisms of corticotroph tumors (CT) remain unclear. The most feasible hypothesis lies in a post-transcriptional deregulation of the POMC gene, precursor of ACTH. Micro RNAs (miRNAs) are small non-coding RNA molecules involved in the epigenetic regulation of gene expression through their inhibitory action on messenger RNA. miRNAs capable of inhibiting the expression of POMC have been described at the level of neurons of the hypot...

Introduction: Bariatric surgery has important metabolic complications such as bone mass loss.Goal: To assess bone mineral density (BMD) after Roux-en-Y gastric by-pass (RYGB) in patients under standard calcium and vitamin D supplementation.Method: In patients with morbid obesity submitted to RYGB, we measured BMD with a dual X-ray densitometer. Using World Health Organization (WHO) criteria’s, values were compared with young c...

Introduction and objectives: Metformin (MTF) is the most used oral antidiabetic drug for the treatment of type 2 diabetes (T2D). However, intolerance to drug is frequent and limits its use. There are controversies about the cause of this problem, the gut microbiota has been proposed to be responsible. The gradual introduction of MTF could exercise an adaptation of gut microbiota that would facilitate tolerance to MTF. In this study we evaluate the metabolic changes and gut mic...

Evaluation of bone quality represents a challenge since the analysis by bone mineral density (BMD), provides useful but incomplete information. New tools are arising, and amog them, TBS is emerging as a new surrogate marker of bone texture and microarchitecture which may be useful to potentially evaluate the risk of bone fracture and can be obtained from already existing BMD scans. Retrospective study of 23 patients with PHH. Clinical, analytical and BMD data were collected fo...

Introduction: Type 2 diabetes mellitus (T2DM) is a risk factor for osteoporotic fractures although bone mineral density is increased. As such, there is a need for improved approaches to estimate fracture risk in such individuals. The Trabecular Bone Score (TBS) is a new technique to determine the trabecular bone microarchitecture.Objective: Our aim was to evaluate evaluate the usefulness of TBS in T2DM patients.Methods: We compared...

Introduction: A multidisciplinary clinic has been developed to optimize the diagnosis and treatment of bone metabolism diseases. Initiated in March 2013, it is carried out simultaneously, once a week by an Endocrinologist and a Rheumatologist.Objective: To describe the experience of this unit in the last 12 months.Material and methods: Cross-sectional observational study. 235 patients were attended from December 2015 to December 20...